Drug and Chemical Toxicology
نویسندگان
چکیده
In the present study, the genotoxic effects of the low-calorie sweetener aspartame (ASP), which is a dipeptide derivative, was investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test, micronucleus test in human lymphocytes and also Ames/Salmonella/ microsome test. ASP induced CAs at all concentrations (500, 1000 and 2000 mg/ml) and treatment periods (24 and 48 h) dosedependently, while it did not induce SCEs. On the other hand, ASP decreased the replication index (RI) only at the highest concentration for 48 h treatment period. However, ASP decreased the mitotic index (MI) at all concentrations and treatment periods dose-dependently. In addition, ASP induced micronuclei at the highest *Correspondence: Dr. Eyyüp Rencüzoğulları, Biology Department, Faculty of Arts and Sciences, Çukurova University, 01330 Adana, Turkey; Fax: +90-3223386070; E-mail: [email protected]. edu.tr.
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